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In eukaryote cells, RNA polymerase III (also called Pol III) is a protein that transcribes DNA to synthesize 5S ribosomal RNA, tRNA, and other small RNAs. The genes transcribed by RNA Pol III fall in the category of "housekeeping" genes whose expression is required in all cell types and most environmental conditions.
Repressor of RNA polymerase III transcription MAF1 homolog is a protein that in humans is encoded by the MAF1 gene. [5] [6] [7] This gene encodes a protein that is homologous to Maf1, a Saccharomyces cerevisiae protein which is highly conserved in eukaryotic cells. S. cerevisiae Maf1 is a negative effector of RNA polymerase III (Pol III). It ...
74414 Ensembl ENSG00000186141 ENSMUSG00000028099 UniProt Q9BUI4 Q9D483 RefSeq (mRNA) NM_001303456 NM_006468 NM_028925 RefSeq (protein) NP_001290385 NP_006459 NP_083201 Location (UCSC) Chr 1: 145.82 – 145.84 Mb Chr 3: 96.62 – 96.63 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse DNA-directed RNA polymerase III subunit RPC3 is an enzyme that in humans is encoded by the POLR3C gene ...
In 1995, A. Gregory Matera et al. first gave the structure its name “perinucleolar compartment” after finding several RNA polymerase III transcripts as well as hnRNPI at the nucleolar rim. [3] Sui Huang et al. has extensively researched the perinucleolar compartment and in 1997 were the first to study the PNC in a large number of human ...
RNA polymerase I synthesizes a pre-rRNA 45S (35S in yeast), which matures and will form the major RNA sections of the ribosome. RNA polymerase II synthesizes precursors of mRNAs and most sRNA and microRNAs. RNA polymerase III synthesizes tRNAs, rRNA 5S and other small RNAs found in the nucleus and cytosol.
The La antigen is a 48kDa transcription termination factor of RNA polymerase III, which associates with the Ro-RNP complex. [16] [17] [24] [25] The mechanism of antibody production in Sjögren's syndrome is not fully understood, but apoptosis (programmed cell death) and molecular mimicry may play a role. [12]
Anti-Scl-70 (also called anti-topoisomerase I after the type I topoisomerase target [1]) is an anti-topoisomerase antibody-type of anti-nuclear autoantibodies, seen mainly in diffuse systemic scleroderma (with a sensitivity of 28–70%), but is also seen in 10–18% of cases of the more limited form of systemic scleroderma called CREST syndrome. [2]
RNA polymerase III 73% of celiac disease subjects tested positive for anti-histone and was the most prevalent, which is typically associated with drug-induced lupus erythematosus . This implicates a high probability of an autoimmune disorder in patients with wheat-related disorders.