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Spironolactone can cause breast pain and breast enlargement in women. [ 128 ] [ 129 ] This is "probably because of estrogenic effects on target tissue." [ 111 ] At low doses, breast tenderness has been reported in only 5% of women, but at high doses, it has been reported in up to 40% of women.
Abdominal pain: 0: 0: ≥11 a: ≥1.7 Polyuria: 2: 0.6: 8: 1.2 Fatigue/lethargy: 1: 0.3: ≥12 a: ≥1.8 Footnotes: a = Precise values unavailable due to inadequate reporting. b = Not monitored in most studies. Description: Side effects of spironolactone (25–400 mg/day) with ≥1% incidence in a 2017 hybrid systematic review of clinical ...
Spironolactone has been identified as an inhibitor of NRG1‐ERBB4 signaling. [142] Spironolactone has been found to act as a potent inhibitor of the pannexin 1 channel, and this action appears to be involved in its antihypertensive effects independently of MR antagonism. [143] Spironolactone has been found to block hERG channels. [144]
While many causes of lower left abdominal pain can be managed at home through lifestyle changes and over-the-counter remedies, persistent or severe symptoms require professional medical evaluation ...
There are several viral infections that can affect the throat and uvula, many of which also cause cold symptoms (runny nose, cough, laryngitis). “Some viruses, like coxsackie (hand, foot, and ...
The lower left abdomen pain in this case can initially be described as a mild discomfort and is typically first connected with constipation. But after 24-48 hours, it may become more severe, sharp ...
In addition to symptoms of hypogonadism and sexual dysfunction, hyperprolactinemia can cause breast changes such as breast pain, breast enlargement, gynecomastia, and galactorrhea. [ 55 ] [ 71 ] [ 72 ] Galactorrhea secondary to hyperprolactinemia is very common in premenopausal women (80%) but more uncommon in individuals with low estrogen ...
Symptoms include one or more of the following: pain in the pubic area, hips, lower back, and thighs. This can take months (or even years) to go away. X-rays taken during the early stages of osteitis pubis can be misleading - pain may be felt, but the damage doesn't appear on the films unless stork views (i.e. standing on one leg) are obtained.