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In Stone Heart Syndrome, this delicate balance is disrupted. The excessive influx or release of calcium from intracellular stores overwhelms the cell's ability to remove it, leading to a sustained contraction state. [1] This prolonged contraction causes the heart muscle to become extremely rigid, resembling stone - hence the syndrome's name.
A coronary CT calcium scan is a computed tomography (CT) scan of the heart for the assessment of severity of coronary artery disease. Specifically, it looks for calcium deposits in atherosclerotic plaques in the coronary arteries that can narrow arteries and increase the risk of heart attack. [1] These plaques are the cause of most heart ...
These calcium ions bind to and open more calcium channels (called ryanodine receptors) located on the sarcoplasmic reticulum within the cell, allowing the flow of calcium out of the SR. These calcium ions are responsible for the contraction of the heart. Calcium also activates chloride channels called I to2, which allow Cl − to enter the cell ...
Positive Bowditch effect causes an increase in cardiac output due to the increased force of contraction of heart muscles. [7]This phenomenon is usually absent or even reversed (negative Bowditch effect) in heart failure and other diseases of heart, such as cardiomyopathy and coronary artery disease.
When it's phosphorylated by PKA, levels of calcium stored in the sarcoplasmic reticulum are increased, allowing a higher rate of calcium being released at the next contraction. However, the increased rate of calcium sequestration also leads to an increase in lusitropy. Sensitizing troponin-C to the effects of calcium.
Women, diabetic individuals, and elderly individuals are more likely to present with atypical symptoms other than chest pain. [8] Women may present with back pain, shortness of breath, heartburn, nausea, and vomiting. [19] Heart disease in women goes undetected prior to a major cardiac event in up to 60% of cases. [19]
Potassium: Vital for heart function, potassium helps maintain a regular heartbeat and supports proper muscle contraction and nerve signaling. It also contributes to fluid balance within the body.
The symptoms of HCM include shortness of breath due to stiffening and decreased blood filling of the ventricles, exertional chest pain (sometimes known as angina) due to reduced blood flow to the coronary arteries, uncomfortable awareness of the heart beat (palpitations), as well as disruption of the electrical system running through the ...
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