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Denosumab, sold under the brand name Prolia among others, is a human monoclonal antibody used for the treatment of osteoporosis, treatment-induced bone loss, metastases to bone, and giant cell tumor of bone.
Along with the rash, atopic dermatitis can cause itchiness and dryness. It can also cause skin to feel warm and swollen. After the rash heals, the skin may have a discoloration to it, the AAD says .
6. Purple spots on your hands and feet. These could be a sign of a bacterial infection of the heart, Kroshinsky said. 7. A circular-shaped rash in an area where Lyme disease is endemic.
Prolia, approved in 2010 to treat bone loss in postmenopausal women and later approved to treat men and women at high risk of fracture, brought in total third-quarter sales of $986 million.
Signs and symptoms [ edit ] A painful and itchy reddish/purple patch of skin that occurs in the same location with repeated exposures to the causative drug is the classic presentation of a fixed drug reaction.
Symptoms often include a rash, joint pain, fever, and lymphadenopathy. It is a type of hypersensitivity , specifically immune complex hypersensitivity ( type III ). The term serum sickness–like reaction (SSLR) is occasionally used to refer to similar illnesses that arise from the introduction of certain non-protein substances, such as ...
“When heat rash develops, your skin is giving you a warning that if this continues, you could really have some severe symptoms, from heat exhaustion to heat stroke,” Katta said.
Miliaria, commonly known as heat rash, sweat rash, or prickly heat, [1] is a skin disease marked by small, itchy rashes due to sweat trapped under the skin by clogged sweat-gland ducts. Miliaria is a common ailment in hot and humid conditions, such as in the tropics and during the summer. [ 2 ]