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Plasmid-mediated resistance is the transfer of antibiotic resistance genes which are carried on plasmids. [1] Plasmids possess mechanisms that ensure their independent replication as well as those that regulate their replication number and guarantee stable inheritance during cell division.
The term plasmid was coined in 1952 by the American molecular biologist Joshua Lederberg to refer to "any extrachromosomal hereditary determinant." [14] [15] The term's early usage included any bacterial genetic material that exists extrachromosomally for at least part of its replication cycle, but because that description includes bacterial viruses, the notion of plasmid was refined over time ...
This process is thought to be a significant cause of increased drug resistance [5] [54] when one bacterial cell acquires resistance, and the resistance genes are transferred to the other species. [ 55 ] [ 56 ] Transposition and horizontal gene transfer, along with strong natural selective forces have led to multi-drug resistant strains of S ...
Pathogenicity islands carry genes encoding one or more virulence factors, including, but not limited to, adhesins, secretion systems (type III and IV secretion system), toxins, invasins, modulins, effectors, superantigens, iron uptake systems, o-antigen synthesis, serum resistance, immunoglobulin A proteases, apoptosis, capsule synthesis, and ...
The surface of bacteria such as E. coli is negatively charged due to phospholipids and lipopolysaccharides on its cell surface, and the DNA is also negatively charged. One function of the divalent cation therefore would be to shield the charges by coordinating the phosphate groups and other negative charges, thereby allowing a DNA molecule to ...
A bacterial DNA transposon. A transposable element (TE), also transposon, or jumping gene, is a type of mobile genetic element, a nucleic acid sequence in DNA that can change its position within a genome, sometimes creating or reversing mutations and altering the cell's genetic identity and genome size.
Viruses also have notable virulence factors. Experimental research, for example, often focuses on creating environments that isolate and identify the role of "niche-specific virulence genes". These are genes that perform specific tasks within specific tissues/places at specific times; the sum total of niche-specific genes is the virus' virulence.
The finO gene of the original F plasmid (in E. coli K12) is interrupted by an IS3 insertion, resulting in constitutive tra operon expression. [12] [13] F + cells also have the surface exclusion proteins TraS and TraT on the bacterial surface. These proteins prevent secondary mating events involving plasmids belonging to the same incompatibility ...