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Aldosterone is the main mineralocorticoid steroid hormone produced by the zona glomerulosa of the adrenal cortex in the adrenal gland. [ 4 ] [ 5 ] It is essential for sodium conservation in the kidney, salivary glands, sweat glands, and colon. [ 6 ]
Causes for this condition are bilateral hyperplasia (excessive tissue growth) of the glands, or aldosterone-producing adenomas (a condition called Conn's syndrome). Primary aldosteronism produces hypertension and electrolyte imbalance, increasing potassium depletion sodium retention.
The outermost layer, the zona glomerulosa is the main site for the production of aldosterone, a mineralocorticoid. The synthesis and secretion of aldosterone are mainly regulated by the renin–angiotensin–aldosterone system. The zona glomerulosa cells express a specific enzyme aldosterone synthase (also known as CYP11B2).
The opposite mechanism is called transrepression. The hormone receptor without ligand binding interacts with heat shock proteins and prevents the transcription of targeted genes. Aldosterone and cortisol (a glucosteroid ) have similar affinity for the mineralocorticoid receptor; however, glucocorticoids circulate at roughly 100 times the level ...
In the adrenal cortex, angiotensin II acts to cause the release of aldosterone. Aldosterone acts on the tubules (e.g., the distal convoluted tubules and the cortical collecting ducts) in the kidneys, causing them to reabsorb more sodium and water from the urine. This increases blood volume and, therefore, increases blood pressure.
Assist in thyroid function and bone growth by osteoblasts; Resilience in bone, teeth, gums, joint, tendon, ligament and skin healing by regulating collagen; Nerve function and healing by regulating myelin; Prevent endometrial cancer by regulating effects of estrogen; Calcitriol: secosteroid (1,25-dihydroxyvitamin D 3) skin/proximal tubule of ...
5) and aldosterone (C 21 H 28 O 5) (cortisone and aldosterone are isomers). The main corticosteroids produced by the adrenal cortex are cortisol and aldosterone. [1] The etymology of the cortico-part of the name refers to the adrenal cortex, which makes these steroid hormones. Thus a corticosteroid is a "cortex steroid". [citation needed]
by the stretch receptors located in the atria of the heart. by adrenoglomerulotropin, a lipid factor, obtained from pineal extracts. It selectively stimulates secretion of aldosterone. The secretion of aldosterone has a diurnal rhythm. Control of aldosterone release from the adrenal cortex: [citation needed] The role of the renin–angiotensin ...