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Patrick Vallance and his London co-workers first noted the interference role for asymmetric dimethylarginine in the early 1990s. [1] Today biochemical and clinical research continues into the role of ADMA in cardiovascular disease, diabetes mellitus, erectile dysfunction and certain forms of kidney disease.
L-Arginine:glycine amidinotransferase (AGAT; EC 2.1.4.1) is the enzyme that catalyses the transfer of an amidino group from L-arginine to glycine. The products are L-ornithine and glycocyamine, also known as guanidinoacetate, the immediate precursor of creatine. Creatine and its phosphorylated form play a central role in the energy metabolism ...
Impairment of DDAH function slows breakdown and increases the level of toxic asymmetrically methylated arginine forms. [ 1 ] Long term exposure to these toxic amino acids is associated with endothelial dysfunction , arterial stiffness , insulin resistance , chronic kidney disease , heart disease , dementia and ageing .
A 2003 study found that a combination of L-arginine and ... Lycopene is also associated with improved general vascular function. ... National Institute of Diabetes and Digestive and Kidney ...
551 11998 Ensembl ENSG00000101200 ENSMUSG00000037727 UniProt P01185 P35455 RefSeq (mRNA) NM_000490 NM_009732 RefSeq (protein) NP_000481 NP_033862 Location (UCSC) Chr 20: 3.08 – 3.08 Mb Chr 2: 130.42 – 130.42 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Human vasopressin, also called antidiuretic hormone (ADH), arginine vasopressin (AVP) or argipressin, is a hormone synthesized ...
Some research shows that L-arginine, found in nitric oxide supplements, could improve fitness performance for runners, cyclists, and swimmers. But, other research has shown little to no effect.
Arginase (EC 3.5.3.1, arginine amidinase, canavanase, L-arginase, arginine transamidinase) is a manganese-containing enzyme. The reaction catalyzed by this enzyme is: arginine + H 2 O → ornithine + urea. It is the final enzyme of the urea cycle. It is ubiquitous to all domains of life.
A 2019 systematic review published by the National Kidney Foundation investigated whether creatine supplementation had adverse effects on renal function. [72] They identified 15 studies from 1997 to 2013 that looked at standard creatine loading and maintenance protocols of 4–20 g/day of creatine versus placebo.
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