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PK/PD relationships can be described by simple equations such as linear model, Emax model or sigmoid Emax model. [5] However, if a delay is observed between the drug administration and the drug effect, a temporal dissociation needs to be taken into account and more complex models exist: [6] [7] Direct vs Indirect link PK/PD models
Interactions can be direct when physical contact is established or indirect, through intermediaries such as shared resources, territories, ecological services, metabolic waste, toxins or growth inhibitors. This type of relationship can be shown by net effect based on individual effects on both organisms arising out of relationship.
Indirect effect in a simple mediation model: The indirect effect constitutes the extent to which the X variable influences the Y variable through the mediator. In linear systems, the total effect is equal to the sum of the direct and indirect (C' + AB in the model above). In nonlinear models, the total effect is not generally equal to the sum ...
This numbering system corresponds loosely to the notions of subject, direct object and indirect object. The numbering scheme is subject → (1), direct object → (2) and indirect object → (3). Other constituents (such as oblique, genitive, and object of comparative) are called nonterms (N). The predicate is marked (P).
Direct realism, also known as naïve realism, argues we perceive the world directly. In the philosophy of perception and philosophy of mind, direct or naïve realism, as opposed to indirect or representational realism, are differing models that describe the nature of conscious experiences; [1] [2] out of the metaphysical question of whether the world we see around us is the real world itself ...
In this theory both direct and indirect passives are derived from the same complementation structure with optional control. There is the assumption that the -(r)are morpheme in direct passives are the same as the ones used in indirect passives meaning that they both have an underlying structure containing the passive morpheme -(r)are .
Direct reciprocity was proposed by Robert Trivers as a mechanism for the evolution of cooperation. [1] If there are repeated encounters between the same two players in an evolutionary game in which each of them can choose either to "cooperate" or "defect", then a strategy of mutual cooperation may be favoured even if it pays each player, in the short term, to defect when the other cooperates.
Indirect method of difference [ edit ] If two or more instances in which the phenomenon occurs have only one circumstance in common, while two or more instances in which it does not occur have nothing in common save the absence of that circumstance; the circumstance in which alone the two sets of instances differ, is the effect, or cause, or a ...
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