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Diabetes in the mother during pregnancy is a significant risk factor for autism; a 2009 meta-analysis found that gestational diabetes was associated with a twofold increased risk. A 2014 review also found that maternal diabetes was significantly associated with an increased risk of autism. [ 55 ]
Several prenatal and perinatal complications have been reported as possible risk factors for autism. [207] These risk factors include maternal gestational diabetes, maternal and paternal age over 30, [208] [209] [210] bleeding during pregnancy after the first trimester, use of certain prescription medication (e.g. valproate) during pregnancy ...
The risk of developing autism is increased in the presence of various prenatal factors, including advanced paternal age and diabetes in the mother during pregnancy. [8] In rare cases, autism is strongly associated with agents that cause birth defects. [9] It has been shown to be related to genetic disorders [10] and with epilepsy. [11]
Some research suggests that a particularly intense immune reaction during gestation might increase the risk of neurodevelopmental ... increase the risk of neurodevelopmental disorders like autism.
The negative effects of pregestational diabetes are due to high blood sugar and insulin levels primarily during the first trimester of pregnancy (in contrast to gestational diabetes, which can lead to fetal complications during the second and third trimester). Since this period is when many of the major internal structures and organs of the ...
Risk factors for self-harm and suicidality include circumstances that could affect anyone, such as mental health problems (e.g., anxiety disorder) and social problems (e.g., unemployment and social isolation), plus factors that affect only autistic people, such as actively trying to behave like a neurotypical person, which is called masking. [93]
The resulting drop in blood sugar level to below the normal range prompts a hunger response. [citation needed] Polydipsia and polyuria occur when blood glucose levels rise high enough to result in excretion of excess glucose via the kidneys, which leads to the presence of glucose in the urine. This produces an osmotic diuresis. [citation needed]
These are normal physiological adaptations that cause changes in behavior, the functioning of the heart, blood vessels, and blood, metabolism including increases in blood sugar levels, kidney function, posture, and breathing. During pregnancy numerous hormones and proteins are secreted that also have a broad range of effects.