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The critical nerves affected are the phrenic nerve (which drives the diaphragm to inflate the lungs) and those that drive the muscles needed for swallowing. By destroying these nerves, this form of polio affects breathing, making it difficult or impossible for the patient to breathe without the support of a ventilator. It can lead to paralysis ...
Polioencephalitis is a viral infection of the brain, causing inflammation within the grey matter of the brain stem. [1] The virus has an affinity for neuronal cell bodies and has been found to affect mostly the midbrain, pons, medulla and cerebellum of most infected patients.
The virus targets the nervous system, which is why it sometimes triggers spinal and respiratory paralysis—and death. Polio primarily infects children under 5 and has done so around the globe for ...
Post-polio syndrome (PPS, poliomyelitis sequelae) is a group of latent symptoms of poliomyelitis (polio), occurring at about a 25–40% rate (latest data greater than 80%). ). They are caused by the damaging effects of the viral infection on the nervous system and typically occur 15 to 30 years after an initial acute paralytic att
A virus that affects nerves in the spinal cord or brain stem causes polio. A young girl using an abacus in a bed at the Columbia Presbyterian Medical Center in New York, circa 1950. Douglas Grundy ...
A few could contract meningitis if the polio virus attacks the covering of the spinal cord or brain. Polio is fatal for 2%-10% of those paralyzed or between 1 in 2,000 to 1 in 10,000 of those ...
The distinct speciation of poliovirus probably occurred as a result of a change in cellular receptor specificity from intercellular adhesion molecule-1 (ICAM-1) (used by C-cluster Coxsackie A viruses) to CD155, leading to a change in pathogenicity and allowing the virus to infect nerve tissue. The mutation rate in the virus is relatively high ...
Polio can cause lifelong paralysis and up to 10% of children who have paralysis from polio die, as the virus affects the muscles that allow them to breathe, the CDC notes.