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Brotizolam is a highly potent and short-acting hypnotic, with a typical dose ranging from 0.125 to 0.25 milligrams, which is rapidly eliminated with an average half-life of 4.4 hours (range 3.6–7.9 hours). [8] It was patented in 1974 [9] and came into medical use in 1984. [10] Brotizolam is not approved for sale in the UK, United States or ...
Federal Aviation Regulation 91.17 (14 CFR 91.17) prohibits pilots from flying aircraft with an alcohol level of 0.04% or more, or within eight hours of consuming alcohol ("eight hours, bottle to throttle"), or while under the impairing influence of any drug. The same prohibition applies to any other crew members on duty aboard the aircraft ...
[8] [7] The mean elimination rates for ethanol are 15 mg/dL per hour for men and 18 mg/dL per hour for women, with a range of 10 to 34 mg/dL per hour. [ 8 ] [ 6 ] At very high concentrations, such as in overdose, it has been found that the rate of elimination of ethanol is increased. [ 5 ]
Blood alcohol content (BAC), also called blood alcohol concentration or blood alcohol level, is a measurement of alcohol intoxication used for legal or medical purposes. [1] BAC is expressed as mass of alcohol per volume of blood. In US and many international publications, BAC levels are written as a percentage such as 0.08%, i.e. there is 0.8 ...
Impairment of performance is seen at BACs of as little as 0.7 mg/mL (0.066%)." ... restricting opening hours of places where alcohol can be bought and consumed;
Outbreaks of methanol poisoning have occurred when methanol is used to adulterate moonshine. [12] Methanol has a high toxicity in humans. If as little as 10 mL of pure methanol is ingested, for example, it can break down into formic acid, which can cause permanent blindness by destruction of the optic nerve, and 30 mL is potentially fatal, [13] although the median lethal dose is typically 100 ...
Disulfiram is a medication used to support the treatment of chronic alcoholism by producing an acute sensitivity to ethanol (drinking alcohol). Disulfiram works by inhibiting the enzyme aldehyde dehydrogenase (specifically the ALDH2 enzyme [3]), causing many of the effects of a hangover to be felt immediately following alcohol consumption.
Finland: for motor vehicles, 0.05%, [80] or 0.22 mg/1 L alcohol in breath, aggravated: 0.12% or 0.53 mg/1 L alcohol in breath. [91] The penalty is a fine or jail up to six months plus license suspension from one month to five years. For aggravated, also a prison sentence (sixty days to two years) is possible, [92] usually as a suspended ...