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The diagnosis of dysplastic nevus syndrome is based on clinical presentation and family history. Treatment consists of resection of malignant skin lesions (melanoma). Screening for pancreatic cancer may be considered, particularly if there is a family history.
Diagnosis is by biopsy and analysis of any skin lesion that has signs of being potentially cancerous. [1] Avoiding UV light and using sunscreen in UV-bright sun conditions may prevent melanoma. [2] Treatment typically is removal by surgery of the melanoma and the potentially affected adjacent tissue bordering the melanoma. [1]
Various differential diagnoses of pigmented skin lesions, including dysplastic nevus, showing the relative incidence of biopsied lesions, and malignancy potential. When an atypical mole has been identified, a skin biopsy takes place in order to best diagnose it. Local anesthetic is used to numb the area, then the mole is biopsied.
Amelanotic melanoma is a type of skin cancer in which the cells do not make any melanin. [1]: 696 [2] They can be pink, red, purple or of normal skin color, and are therefore difficult to diagnose correctly. They can occur anywhere on the body, just as a typical melanoma can.
Cancer can be considered a very large and exceptionally heterogeneous family of malignant diseases, with squamous-cell carcinomas comprising one of the largest subsets. [ 19 ] [ 20 ] [ 21 ] All SCC lesions are thought to begin via the repeated, uncontrolled division of cancer stem cells of epithelial lineage or characteristics.
Cutaneous squamous-cell carcinoma (cSCC), also known as squamous-cell carcinoma of the skin or squamous-cell skin cancer, is one of the three principal types of skin cancer, alongside basal-cell carcinoma and melanoma. [10] cSCC typically presents as a hard lump with a scaly surface, though it may also present as an ulcer. [1]
The resection is an attempt to remove a cancer tumor so that no portion of the malignant growth extends past the edges or margin of the removed tumor and surrounding tissue. These are retained after the surgery and examined microscopically by a pathologist to see if the margin is indeed free from tumor cells (called "negative").
Several lesion types may be classified as MELTUMPs: these include atypical melanocytic proliferations with features that may overlap with atypical Spitz naevi/tumors, dysplastic naevi, pigmented epithelioid melanocytoma, deep penetrating naevi, congenital naevi, cellular nodules in congenital naevi, possible naevoid melanomas, and cellular blue ...