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Tolvaptan, sold under the brand name Samsca among others, is an aquaretic drug that functions as a selective, competitive vasopressin receptor 2 (V 2) antagonist used to treat hyponatremia (low blood sodium levels) associated with congestive heart failure, cirrhosis, and the syndrome of inappropriate antidiuretic hormone (SIADH).
Tolvaptan phosphate is a drug used for the treatment of cardiac edema. It is a prodrug of tolvaptan , [ 1 ] [ 2 ] formulated as the salt tolvaptan sodium phosphate, for intravenous administration .
The second Phase III study with lixivaptan is the ALERT study. [15] The goal of this study is to investigate whether lixivaptan can be safely used in patients with ADPKD who were previously treated with tolvaptan, but who had to permanently discontinue tolvaptan therapy due to liver toxicity .
The longtime college football commentator has little use for Indiana's undefeated record, given its schedule.
tolvaptan, [15] conivaptan: Competitive vasopressin antagonism leads to decreased number of aquaporin channels in the apical membrane of the renal collecting ducts in kidneys, causing decreased water reabsorption.
A home invasion in an upscale Philadelphia suburb turned fatal over the weekend after a suspect broke into a home in Lower Merion Township at 2:20 a.m. on Sunday, Dec. 8, the Montgomery County ...
A Massachusetts man was caught in the middle of some “Santa-antics” and got stuck in a chimney while trying to evade police executing a search warrant on his home.
The "vaptan" drugs act by directly blocking the action of vasopressin at its receptors (V 1A, V 1B and V 2).These receptors have a variety of functions, with the V 1A and V 2 receptors are expressed peripherally and involved in the modulation of blood pressure and kidney function respectively, while the V 1A and V 1B receptors are expressed in the central nervous system.
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