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  2. Hepatotoxicity - Wikipedia

    en.wikipedia.org/wiki/Hepatotoxicity

    Drug-induced liver injury (DILI) is a cause of acute and chronic liver disease caused specifically by medications and the most common reason for a drug to be withdrawn from the market after approval. The liver plays a central role in transforming and clearing chemicals and is susceptible to the toxicity from these agents.

  3. Hy's law - Wikipedia

    en.wikipedia.org/wiki/Hy's_law

    Hy's law is a rule of thumb that a patient is at high risk of a fatal drug-induced liver injury if given a medication that causes hepatocellular injury (not Hepatobiliary injury) with jaundice. [1] The law is based on observations by Hy Zimmerman, a major scholar of drug-induced liver injury.

  4. Liver disease - Wikipedia

    en.wikipedia.org/wiki/Liver_disease

    Analogous terms such as "drug-induced" or "toxic" liver disease are also used to refer to disorders caused by various drugs. [ 7 ] Fatty liver disease (hepatic steatosis ) is a reversible condition where large vacuoles of triglyceride fat accumulate in liver cells. [ 8 ]

  5. Pharmacotoxicology - Wikipedia

    en.wikipedia.org/wiki/Pharmacotoxicology

    Drug-drug interactions can be of serious concern for patients who are undergoing multi-drug therapies. [5] Coadministration of chloroquine , an anti-malaria drug, and statins for treatment of cardiovascular diseases has been shown to cause inhibition of organic anion-transporting polypeptides (OATPs) and lead to systemic statin exposure.

  6. Paracetamol poisoning - Wikipedia

    en.wikipedia.org/wiki/Paracetamol_poisoning

    The increasing liver damage also changes biochemical markers of liver function; International normalized ratio (INR) and the liver transaminases ALT and AST rise to abnormal levels. [14] Acute kidney failure may also occur during this phase, typically caused by either hepatorenal syndrome or multiple organ dysfunction syndrome .

  7. Download, install, or uninstall AOL Desktop Gold - AOL Help

    help.aol.com/articles/aol-desktop-downloading...

    Learn how to download and install or uninstall the Desktop Gold software and if your computer meets the system requirements.

  8. NAPQI - Wikipedia

    en.wikipedia.org/wiki/NAPQI

    NAPQI, also known as NAPBQI or N-acetyl-p-benzoquinone imine, is a toxic byproduct produced during the xenobiotic metabolism of the analgesic paracetamol (acetaminophen). [1] It is normally produced only in small amounts, and then almost immediately detoxified in the liver.

  9. ‘Fleeing into the Unkown’ by Huffington Post

    testkitchen.huffingtonpost.com/Fleeing-into-the...

    Every month, thousands of Eritreans attempt to flee repression, torture and indefinite forced conscriptions by embarking on a dangerous journey to Europe.