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Donepezil, sold under the brand name Aricept among others, is a medication used to treat dementia of the Alzheimer's type. [3] [4] [8] It appears to result in a small benefit in mental function and ability to function. [9] Use, however, has not been shown to change the progression of the disease. [10] Treatment should be stopped if no benefit ...
Galantamine is a type of acetylcholinesterase inhibitor.It is an alkaloid extracted from the bulbs and flowers of Galanthus nivalis (common snowdrop), Galanthus caucasicus (Caucasian snowdrop), Galanthus woronowii (Voronov's snowdrop), and other members of the family Amaryllidaceae, such as Narcissus (), Leucojum aestivum (snowflake), and Lycoris including Lycoris radiata (red spider lily). [5]
Benzgalantamine is a prodrug of galantamine. [1] The most common side effects include nausea, vomiting, diarrhea, dizziness, headache, and decreased appetite. [1] Benzgalantamine was approved for medical use in the United States in July 2024. [1] [2] [3]
Acetylcholinesterase inhibitors, like donepezil, rivastigmine, and galantamine, have been used in the treatment of disorders of diminished motivation. [ 17 ] [ 18 ] [ 6 ] [ 11 ] These drugs inhibit acetylcholinesterase , which metabolizes the neurotransmitter acetylcholine , thereby increasing acetylcholine levels in the brain and augmenting ...
Paraoxon and rivastigmine are both acetylcholinesterase inhibitors and butyrylcholinesterase inhibitors. [14] [11] [7]In 2015, the United States Food and Drug Administration's Adverse Event Reporting System database compared rivastigmine to the other ChEI drugs donepezil and galantamine found that rivastigmine was associated with a higher frequency of reports of death as an adverse event.
Memantine when added to donepezil in those with moderate-to-severe dementia resulted in "limited improvements" in a 2017 review. [24] The UK National Institute for Clinical Excellence (NICE) issued guidance in 2018 recommending consideration of the combination of memantine with donepezil in those with moderate-to-severe dementia.
In the Medical Uses section, it would be helpful to note that the US FDA approved donepezil for mild, moderate, and severe dementia in Alzheimer's, rather than just severe dementia. In the Adverse Effects section, some of the sentences need references, and adding in the frequencies for each of the mentioned adverse effects would be helpful.
Galantamine; Caffeine – noncompetitive (also an adenosine receptor antagonist) [23] Rosmarinic acid – ester of caffeic acid. Found in plants species of family Lamiaceae. [24] Alpha-pinene – noncompetitive reversible [25] [26] Piperidines. Donepezil; Tacrine, also known as tetrahydroaminoacridine (THA) Edrophonium; Huperzine A [27] [28 ...
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