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Chronic lymphocytic leukemia (CLL) is a type of cancer in which the bone marrow makes too many lymphocytes (a type of white blood cell). [ 2 ] [ 8 ] Early on, there are typically no symptoms. [ 2 ] Later, non-painful lymph node swelling, feeling tired, fever , night sweats , or weight loss for no clear reason may occur.
A subgroup of CLL/SLL (~23% of all cases) develop "accelerated" CLL, i.e. malignant B lymphocytes that are proliferating rapidity. [11] Individuals with accelerated CCL/SLL show worsening symptoms and signs as well as a microscopic histopathology of their involved tissues that can be difficult to distinguish from RTs. [10]
The presence of B symptoms is a marker for more advanced disease with systemic, rather than merely local, involvement. B symptoms are a clear negative prognostic factor in Hodgkin lymphoma. [2]
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Chronic lymphocytic leukemia, including Hairy cell leukemia; Myeloproliferative neoplasms including polycythemia vera, essential thrombocythemia, primary myelofibrosis, chronic neutrophilic leukemia , and chronic eosinophilic leukemia
Signs and symptoms of chronic lymphocytic leukemia commonly precede those of multiple myeloma, sometimes by years. [38] The relationship between the two clones of cells in this combined disease has not been established although one study suggests that the clonal plasma cells and clonal lymphocytes arise from a common hematological stem cell. [39]
Lymphoproliferative disorders are a set of disorders characterized by the abnormal proliferation of lymphocytes into a monoclonal lymphocytosis.The two major types of lymphocytes are B cells and T cells, which are derived from pluripotent hematopoietic stem cells in the bone marrow.
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