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Depo-Provera, Depo-SubQ Provera 104, others: AHFS/Drugs.com: depo-provera: Failure rates (first year) Perfect use: 0.2% [37] Typical use: 6% [37] Usage; Duration effect: 3 months (12–14 weeks) Reversibility: 3–18 months: User reminders: Maximum interval is just under 3 months: Clinic review: 12 weeks: Advantages and disadvantages; STI ...
Medroxyprogesterone acetate (brand names Depo-Provera, Provera, Depo-subQ Provera 104) [4] – 150 mg (intramuscularly) or 104 mg (subcutaneously) every 3 months [3] Norethisterone enanthate (brand names NET EN, Noristerat, Norigest, Doryxas) [ 5 ] – 200 mg (intramuscularly) every 2 months [ 3 ]
Depot MPA (DMPA) and EC/MPA were developed by Upjohn in the 1960s. [12] [13] DMPA (brand name Depo-Provera) was introduced for use as a progestogen-only injectable contraceptive for the first time outside of the United States in 1969 and was subsequently approved for use in birth control in the United States in 1992.
CICs are different from progestogen-only injectable contraceptives (POICs), such as depot medroxyprogesterone acetate (DMPA; brand names Depo-Provera, Depo-SubQ Provera 104) and norethisterone enantate (NETE; brand name Noristerat), which are not combined with an estrogen and are given once every two to three months instead of once a month. [2]
Depo-Estradiol: Estrogen: IM, SC: 2–10 mg/wk or 5–20 mg every 2 wks ... Depo-SubQ Provera 104: Progestogen: SC: 104 mg every 3 mos Hydroxyprogesterone caproate:
Depo-Provera is used by 2.9%, primarily younger women (7.5% of those 15-19 and about 4.5% of those 20–30). [78] A 2013 Lancet systematic literature review found that among reproductive aged women in a marriage or union, 66% worldwide and 77% in the United States use contraception.
Vial of Depo-Testosterone, a depot injection of testosterone. A depot injection, also known as a long-acting injectable (LAI), is a term for an injection formulation of a medication which releases slowly over time to permit less frequent administration of a medication.
Also it is not clear how rapidly it is hydrolyzed. Hence it may not be a true prodrug. Finally MPA is the active ingredient of Depo-Provera which can be used as a injectable contraceptive whose effects last for months. Hence the reason for the acetate ester maybe to increase the hydrophobicity and thereby increase the half-life of the drug.
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