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Sonrotoclax is an investigational new drug that is being evaluated for the treatment of hematologic malignancies, particularly chronic lymphocytic leukemia (CLL) and small lymphocytic lymphoma (SLL). [1]
Benzamide is an organic compound with the chemical formula of C 7 H 7 NO. It is the simplest amide derivative of benzoic acid. In powdered form, it appears as a white solid, while in crystalline form, it appears as colourless crystals. [5] It is slightly soluble in water, [2] and soluble in many organic solvents. [6]
GR-55562 is a selective serotonin 5-HT 1B and 5-HT 1D receptor antagonist. [1] It is one of several selective serotonin 5-HT 1B receptor antagonists used in scientific research. [2] [3]
The affinity (K i) of AZD-7268 for the δ-opioid receptor was reported to be 2.7 nM and its selectivity for this receptor over the μ-opioid receptor was reported to be 2,000-fold. [4] No animal studies of AZD-7268 appear to have been published. [3] [4] In addition to putative antidepressant effects, AZD-7268 might have anxiolytic effects.
U-77891 is an opioid analgesic drug that was first synthesized in 1983 by the Upjohn company. [1] It was originally synthesized to prove that the removal of a single methylene spacer of the benzamide would alter a κ-opioid receptor agonist such as U-50488 into an μ-opioid receptor agonist, as well as producing a semi-rigid derivative of U-47700.
Sultopride (trade names Barnetil, Barnotil, Topral) is an atypical antipsychotic of the benzamide chemical class used in Europe, Japan, and Hong Kong for the treatment of schizophrenia. [2] [3] [4] It was launched by Sanofi-Aventis in 1976. [2] Sultopride acts as a selective D 2 and D 3 receptor antagonist. [5]
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