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Persister cells have entered a non-growing, or extremely slow-growing physiological state which makes them tolerant (insensitive or refractory) to the action of antimicrobials. When such persisting pathogenic microbes cannot be eliminated by the immune system, they become a reservoir from which recurrence of infection will develop. [ 10 ]
Natural transformation is a process of DNA transfer between cells, and is regarded as a form of bacterial sexual interaction. In the fruit fly Drosophila melanogaster , exposure to mitomycin C increases recombination during meiosis, a key stage of the sexual cycle. [ 5 ]
These dormant cancer cells are often untreatable due to drug resistance. These cells are usually resistant to chemotherapy because they are not dividing, and chemotherapy best targets rapidly diving cells. [1] [7] [15] [16] An idea for a therapeutic strategy is to cause cancer cells to be induced or maintained in a dormant state.
The systems of the body most affected by chemotherapy drugs include visual and semantic memory, attention and motor coordination and executive functioning. [9] [10] These effects can impair a chemotherapy patient's ability to understand and make decisions regarding treatment, perform in school or employment and can reduce quality of life. [10]
In TLS, the breakdown occurs after cytotoxic therapy or from cancers with high cell turnover and tumor proliferation rates. [4] The metabolic abnormalities seen in tumor lysis syndrome can ultimately result in serious complications such as acute uric acid nephropathy, acute kidney failure, seizures, cardiac arrhythmias, and death. [6] [7]
Elle Macpherson has revealed she has been secretly battling breast cancer, but is now in remission despite refusing chemotherapy against the advice of “32 doctors and experts”.
You may have heard of ‘chemo brain;’ some chemo patients describe experiencing memory problems, difficulty concentrating, and a feeling of mental fogginess during or after chemotherapy.”
It remained there long after I finished chemo, and instead I wore a gray cashmere cap my mom had bought me. Cozy and warm, it was exactly what I needed at that point. I wore it until I had enough ...