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Microsoft Defender Antivirus (formerly Windows Defender) is an antivirus software component of Microsoft Windows.It was first released as a downloadable free anti-spyware program for Windows XP and was shipped with Windows Vista and Windows 7.
The term "on-demand scan" refers to the possibility of performing a manual scan (by the user) on the entire computer/device, while "on-access scan" refers to the ability of a product to automatically scan every file at its creation or subsequent modification.
SmartScreen (officially called Windows SmartScreen, Windows Defender SmartScreen and SmartScreen Filter in different places) is a cloud-based anti-phishing and anti-malware component included in several Microsoft products: All versions of the Microsoft Windows operating system since Windows 8; Web browsers Internet Explorer and Microsoft Edge
Malwarebytes is primarily a scanner that scans and removes malicious software, including rogue security software, adware, and spyware.Malwarebytes scans in batch mode, rather than scanning all files opened, reducing interference if another on-demand anti-malware software is also running on the computer.
McAfee changed the way scheduled scans start to stop your computer from starting a scan while you're actively using it. Your McAfee software starts monitoring your computer for activity. If no keyboard or mouse activity occurs for 10 minutes, your McAfee software then monitors for CPU use.
The latest version of 4.10 was released on 29 November 2016. It was version 4.10.209.0 for Windows Vista and Windows 7. This update fixes a bug that was introduced earlier in version 4.10.205.0 which removed the "Scan with Microsoft Security Essentials" entry from the right-click context menu on files and folders.
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Since support for Windows 2000 ended on July 13, 2010, Microsoft stopped distributing the tool to Windows 2000 users via Windows Update. The last version of the tool that could run on Windows 2000 was 4.20, released on May 14, 2013. Starting with version 5.1, released on June 11, 2013, support for Windows 2000 was dropped altogether.