Search results
Results from the WOW.Com Content Network
Alpha-mannosidosis is a lysosomal storage disorder, [1] first described by Swedish physician Okerman in 1967. [2] In humans it is known to be caused by an autosomal recessive genetic mutation in the gene MAN2B1, located on chromosome 19, affecting the production of the enzyme alpha-D-mannosidase, resulting in its deficiency.
Generalized anxiety disorder is "characterized by chronic excessive worry accompanied by three or more of the following symptoms: restlessness, fatigue, concentration problems, irritability, muscle tension, and sleep disturbance". [13] Generalized anxiety disorder is the most common anxiety disorder to affect older adults. [14]
Mannose (D-mannose) is used as a dietary supplement to prevent recurrent urinary tract infections (UTIs). [ 9 ] [ 10 ] As of 2022 [update] , one review found that taking mannose was as effective as antibiotics to prevent UTIs, [ 9 ] while another review found that clinical trial quality was too low to allow any conclusion about using D ...
Hydrolysis of terminal, non-reducing β-D-mannose residues in β-D-mannosides This gene encodes a member of the glycosyl hydrolase 2 family . The encoded protein localizes to the lysosome where it is the final exoglycosidase in the pathway for N -linked glycoprotein oligosaccharide catabolism.
Antisocial personality disorder is listed here and in the chapter on personality disorders (but ADHD is listed under neurodevelopmental disorders). [11] Symptoms for oppositional defiant disorder are of three types: angry/irritable mood, argumentative/defiant behavior, and vindictiveness. The conduct disorder exclusion is deleted.
For example, a diagnosis of major depressive disorder, a common mental illness, had a poor reliability kappa statistic of 0.28, indicating that clinicians frequently disagreed on diagnosing this disorder in the same patients. The most reliable diagnosis was major neurocognitive disorder, with a kappa of 0.78. [102]
Anxiety disorders and major depressive disorder occur in a minority of individuals with ADHD, but more often than in the general population. [145] Further research suggests that about 20 to 40 percent of individuals with attention deficit hyperactivity disorder have comorbid anxiety disorders, with GAD being the most prevalent. [146]
More generally, negative or stressful life events have been implicated in the development of a range of disorders, including mood and anxiety disorders. [75] [76] The main risks appear to be from the accumulation of such experiences over time, although a single major trauma can sometimes lead to disorders, especially post-traumatic stress disorder.