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Post-exposure prophylaxis, also known as post-exposure prevention (PEP), is any preventive medical treatment started after exposure to a pathogen in order to prevent the infection from occurring. It should be contrasted with pre-exposure prophylaxis , which is used before the patient has been exposed to the infective agent.
Treatment of Clostridioides (formerly Clostridium) difficile infection. [8] May be more narrow-spectrum than vancomycin, resulting in less bowel microbiota alteration. [9] Nausea (11%), vomiting, and abdominal pain. [10] Bactericidal in susceptible organisms such as C. difficile by inhibiting RNA polymerase, thereby inhibiting protein synthesis ...
Until this point, researchers debated whether syphilis and gonorrhea were manifestations of the same disease or two distinct entities. [89] [9] One such 18th-century researcher, John Hunter, tried to settle the debate in 1767 [9] by inoculating a man with pus taken from a patient with gonorrhea. He erroneously concluded that syphilis and ...
Arsphenamine was prepared as part of a campaign to synthesize a series of such compounds, and was found to exhibit partially selective toxicity. Arsphenamine proved to be the first effective treatment for syphilis, a disease untl then had been incurable and led inexorably to severe skin ulceration, neurological damage, and death. [16]
Medicine is the science [1] and practice [2] of caring for patients, managing the diagnosis, prognosis, prevention, treatment, palliation of their injury or disease, and promoting their health. Medicine encompasses a variety of health care practices evolved to maintain and restore health by the prevention and treatment of illness.
Syphilis. The third stage of syphilis also manifests as aneurysm of the aorta, which is due to loss of the vasa vasorum in the tunica adventitia. [28] Copper deficiency. A minority of aneurysms are caused by copper deficiency, which results in a decreased activity of the lysyl oxidase enzyme, affecting elastin, a key component in vessel walls.
Bismuth compounds (including sodium bismuth tartrate) were formerly used to treat syphilis. [79] [80] Arsenic combined with either bismuth or mercury was a mainstay of syphilis treatment from the 1920s until the advent of penicillin in 1943. [81]
Hematin and heme arginate is the treatment of choice during an acute attack. Heme is not a curative treatment, but can shorten attacks and reduce the intensity of an attack. Side-effects are rare but can be serious. [citation needed] Pain is extremely severe and almost always requires the use of opiates to reduce it to tolerable levels. Pain ...
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