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Setting aside other factors (e.g., balancing selection, and genetic drift), the equilibrium number of deleterious alleles is then determined by a balance between the deleterious mutation rate and the rate at which selection purges those mutations. Mutation–selection balance was originally proposed to explain how genetic variation is ...
Selection acts on variation in phenotypes, which are often the result of mutations in protein-coding genes. The genetic code is written in DNA sequences as codons , groups of three nucleotides . Each codon represents a single amino acid in a protein chain.
The Haldane-Muller theorem of mutation–selection balance says that the load depends only on the deleterious mutation rate and not on the selection coefficient. [6] Specifically, relative to an ideal genotype of fitness 1, the mean population fitness is exp ( − U ) {\displaystyle \exp(-U)} where U is the total deleterious mutation rate ...
Mutation is a genetic operator used to maintain genetic diversity of the chromosomes of a population of an evolutionary algorithm (EA), including genetic algorithms in particular. It is analogous to biological mutation .
Balancing selection refers to a number of selective processes by which multiple alleles (different versions of a gene) are actively maintained in the gene pool of a population at frequencies larger than expected from genetic drift alone. Balancing selection is rare compared to purifying selection. [1]
The adaptive value can be measured by contribution of an individual to the gene pool of their offspring. The adaptive values are approximately calculated from the rates of change in frequency and mutation–selection balance. [2]
Human-based selection strategy is a simplest human-based evolutionary computation procedure. It is used heavily today by websites outsourcing collection and selection of the content to humans (user-contributed content).
Selection coefficient, usually denoted by the letter s, is a measure used in population genetics to quantify the relative fitness of a genotype compared to other genotypes. . Selection coefficients are central to the quantitative description of evolution, since fitness differences determine the change in genotype frequencies attributable to selecti