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Nanoparticle drug delivery systems are engineered technologies that use nanoparticles for the targeted delivery and controlled release of therapeutic agents. The modern form of a drug delivery system should minimize side-effects and reduce both dosage and dosage frequency. Recently, nanoparticles have aroused attention due to their potential ...
This was a huge breakthrough in the nanoparticle drug delivery field, and it helped advance research and development toward clinical trials of nanoparticle delivery systems. Nanoparticles range in size from 10 - 1000 nm (or 1 μm) and they can be made from natural or artificial polymers , lipids , dendrimers , and micelles .
One example of an ABC transporter is P-glycoprotein (P-gp). These transporters use ATP to efflux drugs out of the cell before they can exhibit their cytotoxic effects. [3] Nanoparticles with MDR-1 silencing siRNA along with a cytotoxic drug PTX. Using this nanoparticle for delivery, silencing of the MDR-1 gene was achieved.
Other potential applications of magnetic nanoparticles are brain imaging and drug delivery past the blood-brain barrier (BBB) using biodegradable magnetic iron oxide nanoparticles. The scope of this application is the treatment of central nervous system (CNS) disorders by functioning as contrast agents and drug carriers.
The opportunity for functionalizing nanoparticles in such ways is especially beneficial when targeting areas of the body that have certain physiochemical properties that prevent the intended drug from reaching the targeted area alone; for example, some nanoparticles are able to bypass the Blood Brain Barrier to deliver therapeutic drugs to the ...
Gold nanoparticles that act as drug delivery systems in conjugation with chemotherapeutic drugs typically range in size from 10 to 100 nm. [ 2 ] Surface area plays a very important role in drug delivery and per mg of gold, as diameters decrease, the surface areas needed to transport drugs increase to the point where a single 1mL volume of 1.8 ...
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