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Streptomyces psammoticus Virgilio and Hengeller 1960 (Approved Lists 1980) Kitasatospora aureofaciens is a species of Kitasatospora , and the source of many tetracycline antibiotics . [ 1 ] The organism was first isolated at Sanborn Field on the University of Missouri campus in Columbia, Missouri , US; the site became a National Historic Landmark .
Streptomyces is the largest genus of Actinomycetota, and the type genus of the family Streptomycetaceae. [3] Over 700 species of Streptomyces bacteria have been described. [ 4 ] [ 5 ] [ 6 ] As with the other Actinomycetota, streptomycetes are gram-positive , and have very large genomes with high GC content .
Duggar derived the substance from a Missouri soil sample, golden-colored, fungus-like, soil-dwelling bacterium named Streptomyces aureofaciens. [42] About the same time as Lederle discovered aureomycin, Pfizer was scouring the globe for new antibiotics. Soil samples were collected from jungles, deserts, mountaintops, and oceans.
Streptomyces isolates have yielded the majority of human, animal, and agricultural antibiotics, as well as a number of fundamental chemotherapy medicines. Streptomyces is the largest antibiotic -producing genus of Actinomycetota , producing chemotherapy, antibacterial, antifungal , antiparasitic drugs, and immunosuppressants . [ 1 ]
Triacsin C is an inhibitor of long fatty acyl CoA synthetase that has been isolated from Streptomyces aureofaciens. [1] [2] [3] It blocks β-cell apoptosis, induced by fatty acids (lipoapoptosis) in a rat model of obesity.
Chlortetracycline (trade name Aureomycin, Lederle Laboratories) is a tetracycline antibiotic, the first tetracycline to be identified. It was discovered in 1945 at Lederle Laboratories under the supervision of scientist Yellapragada Subbarow and Benjamin Minge Duggar.
Streptomyces purpureus (Matsumae & Hata 1968) Goodfellow et al. 1986 ... K. aureofaciens "Streptomyces rubellomurinus" Okuhara et al. 1980. K. atroaurantiaca.
Demeclocycline (INN, BAN, USAN, brand name Declomycin) is a tetracycline antibiotic which was derived from a mutant strain of Streptomyces aureofaciens. [ 1 ] [ 2 ] Uses