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Neurodegenerative diseases can disrupt the normal human homeostasis and result in abnormal estrogen levels. For example, neurodegenerative diseases can cause different physiological effects in males and females. In particular, estrogen studies have revealed complex interactions with neurodegenerative diseases.
Vaginal estrogen is a form of estrogen that is delivered by intravaginal administration. Vaginally administered estrogens are thereby exerting their effects mainly in the nearby tissue, with more limited systemic effects compared to orally administered estrogens. [ 1 ]
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Side effects of estradiol acetate include breast tenderness, breast enlargement, nausea, headache, and fluid retention. [7] [5] [6] Estradiol acetate is an estrogen and hence is an agonist of the estrogen receptor, the biological target of estrogens like estradiol. [8] [9] It is an estrogen ester and a prodrug of estradiol in the body.
Therapy can take the form of an estrogen pill, skin patch, ring, gel, cream, or spray, and it usually includes a second hormone, progestogen, which can be either progesterone or a synthetic progestin.
“The symptoms can vary from person to person but often include: changes in menstrual cycle, hot flashes, night sweats, vaginal dryness, mood swings, weight gain, disrupted sleep, foggy brain and ...
Estrogen can also reduce vaginal atrophy and increase sexual arousal, frequency and orgasm. [22] The effectiveness of hormone replacement can decline in some women after long-term use. [22] A number of studies have also found that the combined effects of estrogen/androgen replacement therapy can increase libido and arousal over estrogen alone. [22]
Topical estrogen creams have been touted as a solution to skin aging due to menopause for decades— but they may not be right for you.