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Lactulose is a non-absorbable sugar used in the treatment of constipation and hepatic encephalopathy. [3] [4] It is administered orally for constipation, and either orally or rectally for hepatic encephalopathy. [3] It generally begins working after 8–12 hours, but may take up to 2 days to improve constipation. [1] [2]
Although neither Pablum nor its biscuit predecessor [6] was the first food designed and sold specifically for babies, it was the first baby food to come precooked and thoroughly dried. The ease of preparation made Pablum successful in an era when infant malnutrition was still a major problem in industrialized countries. [7]
Constipation is a potential problem, particularly among infants, elderly and pregnant women. In infants, formula feeding may be associated with constipation and hard stools. [12] Galactooligosaccharides may improve stool frequency and relieve symptoms related to constipation. [13]
Especially in infants, changes in formula or transitioning from breast milk to formula can cause constipation. 95% of cases of constipation in children are thought to be functional constipation (without a structural or biochemical cause). [2] Treatment of these functional causes can be focused on simply relieving the symptoms. [6]
Constipation is the most common chronic gastrointestinal disorder in adults. Depending on the definition employed, it occurs in 2% to 20% of the population. [18] [58] It is more common in women, the elderly and children. [58] Specifically constipation with no known cause affects females more often affected than males. [59]
However it is important to note that even this type of infant formula is far from the natural abundance of nearly 200 HMOs present in human milk. Irritable bowel syndrome: Human milk oligosaccharides are also used to treat the symptoms of irritable bowel syndrome (IBS), which is a gastrointestinal disorder affecting 10–15% of the developed world.
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Lactitol is a laxative and is used to prevent or treat constipation, [5] e.g., under the trade name Importal. [6] [7] In February 2020, Lactitol was approved for use in the United States as an osmotic laxative for the treatment of chronic idiopathic constipation (CIC) in adults. [8] [9] [10]
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