Search results
Results from the WOW.Com Content Network
Tuberous sclerosis proteins 1 and 2, also known as TSC1 (hamartin) and TSC2 (tuberin), form a protein-complex. The encoding two genes are TSC1 and TSC2. The complex is known as a tumor suppressor. Mutations in these genes can cause tuberous sclerosis complex.
Pharmacological inhibition of ERK1/2 restores GSK3β activity and protein synthesis levels in a model of tuberous sclerosis. [8]The defective degradation of glycogen by the autophagy-lysosome pathway is, at least in part, independent of impaired regulation of mTORC1 and is restored by the combined use of PKB/Akt and mTORC1 pharmacological inhibitors.
TSC1 functions as a co-chaperone which inhibits the ATPase activity of the chaperone Hsp90 (heat shock protein-90) and decelerates its chaperone cycle. TSC1 functions as a facilitator of Hsp90 in chaperoning the kinase and non-kinase clients including TSC2, therefore preventing their ubiquitination and degradation in the proteasome. [6]
Get answers to your AOL Mail, login, Desktop Gold, AOL app, password and subscription questions. Find the support options to contact customer care by email, chat, or phone number.
A review that considered berberine’s effects on heart health found some studies supporting this claim, but due to the high risk of bias, the researchers recommended more clinical trials be ...
Costco membership also gives shoppers access to the club's travel deals. The company revealed its largest booking in the last year was a 150-day cruise around the world.. CFO Gary Millerchip said ...
"The Lost Children" tells the true story of the Mucutuy siblings, four children who survived for 40 days in the Colombian Amazon following a tragic plane crash that killed all adults onboard.. The ...
On July 14, 2022, YouTube made a special playlist and video celebrating the 317 music videos to have hit 1 billion views and joined the "Billion Views Club". [ 65 ] [ 66 ] On April 1, 2024, the communications app Discord incorporated a short trailer video into their in-app April Fools' Day prank regarding loot boxes .