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A loading dose is most useful for drugs that are eliminated from the body relatively slowly, i.e. have a long systemic half-life. Such drugs need only a low maintenance dose in order to keep the amount of the drug in the body at the appropriate therapeutic level, but this also means that, without an initial higher dose, it would take a long ...
Neonatal epilepsy may be credited to genetic syndromes, developmental structural brain abnormalities, or metabolic diseases. [10] The incidence of seizures is more common in the neonatal stage than in other stages of life. [11] Neonatal seizures are comparatively rare and affect 1 or 3.5 in 1000 infants born. [12]
Levetiracetam, sold under the brand name Keppra among others, is a novel antiepileptic drug [7] used to treat epilepsy. [8] It is used for partial-onset , myoclonic , or tonic–clonic seizures, [ 7 ] and is taken either by mouth as an immediate or extended release formulation or by injection into a vein .
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They may persist beyond infancy, or, rarely, commence only later in childhood. Many individuals with the syndrome go on to develop other forms of epilepsy later in life (notably Lennox–Gastaut syndrome), and persisting neurodevelopmental deficits are common; [2] notably, up to about a third of children are subsequently diagnosed with autism. [6]
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Several studies that followed children exposed to ASMs during pregnancy showed that a number of widely used ones (including lamotrigine and levetiracetam) carried a low risk of adverse neurodevelopmental outcomes (cognitive and behavioral) in children when compared to children born to mothers without epilepsy and children born to mothers taking ...