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Guidelines on the choice of agents and how best to step up treatment for various subgroups in hypertension (high blood pressure) have changed over time and differ between countries. A Comparison of International Guidelines on Goal Blood Pressure and Initial Therapy for Adults With Hypertension (adapted from JNC 8 guidelines [ 1 ] )
Dapagliflozin is an example of an SGLT-2 inhibitor, it is a competitive, highly selective inhibitor of SGLT. It acts via selective and potent inhibition of SGLT-2, and its activity is based on each patient's underlying blood sugar control and kidney function. The results are decreased kidney reabsorption of glucose, glucosuria effect increases ...
[2] [3] SGLT1, encoded by the SLC5A1 gene, is primarily expressed in the late proximal tubule (S3 segment) and accounts for the remaining 3% of glucose reabsorption. [2] [3] In addition to SGLT1 and SGLT2, there are 10 other members in the human protein family SLC5A. [4] SLC5A4, also known as SGLT3, is a member of the sodium-glucose ...
SGLT2 is a member of the sodium glucose cotransporter family, which are sodium-dependent glucose transport proteins. SGLT2 is the major cotransporter involved in glucose reabsorption in the kidney. [6] SGLT2 is located in the early proximal tubule, and is responsible for reabsorption of 80-90% of the glucose filtered by the kidney glomerulus. [7]
Blocking SGLT-2 reduces blood glucose by blocking glucose reabsorption in the kidney and thereby excreting glucose (i.e., blood sugar) via the urine. [43] [44] [45] Of all the SGLT-2 Inhibitors currently available, empagliflozin has the highest degree of selectivity for SGLT-2 over SGLT-1, SGLT-4, SGLT-5 and SGLT-6. [46]
Are you team canned or team fresh cranberry sauce?. This Thanksgiving, we're answering plenty of your burning, commonly-searched food questions.Here, we're tackling the nutritional facts behind ...
Bexagliflozin, sold under the brand name Brenzavvy, is an antidiabetic medication used to improve glycemic control in adults with type 2 diabetes. [3] [4] It is a sodium-glucose cotransporter 2 (SGLT2) inhibitor that is taken by mouth. [1] [2] The most common side effects include genital yeast infections, urinary tract infections, and increased ...
The Washington Post argued in a new editorial that the benefits of gender-transition treatments for minors like puberty blockers have not been scientifically proven. "Treatment results that look ...