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Phage therapy is the use of bacteriophages to treat bacterial infections. Bacteriophage treatment offers a possible alternative to conventional antibiotic treatments for bacterial infection. [55] It is conceivable that, although bacteria can develop resistance to phages, the resistance might be easier to overcome than resistance to antibiotics.
Structural model at atomic resolution of bacteriophage T4 [1] The structure of a typical myovirus bacteriophage Anatomy and infection cycle of bacteriophage T4.. A bacteriophage (/ b æ k ˈ t ɪər i oʊ f eɪ dʒ /), also known informally as a phage (/ ˈ f eɪ dʒ /), is a virus that infects and replicates within bacteria and archaea.
He was co-discoverer of bacteriophages (viruses that infect bacteria) and experimented with the possibility of phage therapy. [2] D'Hérelle has also been credited for his contributions to the larger concept of applied microbiology. [3] d'Hérelle was a self-taught microbiologist.
The phi X 174 (or ΦX174) bacteriophage is a single-stranded DNA virus that infects Escherichia coli. This virus was isolated in 1935 by Nicolas Bulgakov [1] in Félix d'Hérelle's laboratory at the Pasteur Institute, from samples collected in Paris sewers. Its characterization and the study of its replication mechanism were carried out from ...
Phage "organismal" ecology is the most closely aligned of phage ecology disciplines with the classical molecular and molecular genetic analyses of bacteriophage. From the perspective of ecological subdisciplines , we can also consider phage behavioral ecology , functional ecology , and physiological ecology under the heading of phage ...
Generalized transduction is a rare event and occurs on the order of 1 phage in 11,000. [citation needed] The new virus capsule that contains part bacterial DNA then infects another bacterial cell. When the bacterial DNA packaged into the virus is inserted into the recipient cell three things can happen to it: [citation needed] [5]
This problem prompted researchers to look towards other possible regulators of bacterial growth, like Autographiviridae bacteriophages. [5] This type of treatment is referred to as phage therapy. Phage therapy is effective against drug-resistant bacteria because bacteriophages are naturally inclined to infect and kill specific bacteria. [7]
The sequencing results support the hypothesis that phage P22 is a virus that has evolved through extensive recombination with other viruses. [1] P22 research has focused on its differences from bacteriophage λ including the mechanisms by which it circularizes DNA upon infection and packages DNA into the virion. [3]