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Triiodothyronine, also known as T 3, is a thyroid hormone. It affects almost every physiological process in the body, including growth and development, metabolism, body temperature, and heart rate. [1] Production of T 3 and its prohormone thyroxine (T 4) is activated by thyroid-stimulating hormone (TSH
Liothyronine is the most potent form of thyroid hormone. As a salt of triiodothyronine (T 3), it is chemically similar and pharmacologically equivalent to T 3. As such, it acts on the body to increase the basal metabolic rate, affect protein synthesis and increase the body's sensitivity to catecholamines (such as adrenaline) by permissiveness.
Desiccated Thyroid became a commercial treatment option in 1934 with Westhroid, [citation needed]. In the early 1960s, desiccated thyroid hormones (thyroid extract) began to be replaced by levothyroxine (synthetic T4), or by combinations of T4 and T3. Replacement occurred faster in the United Kingdom than in North America, but by the 1980s more ...
“Levothyroxine is a very common medication because thyroid problems become more likely as we age. ... This in turn causes the thyroid to produce T3 and T4, which play a role in the ...
The T4 → T3 conversion is mediated by the selenoenzyme iodothyronine deiodinase. T3-thyroxine is a unique example of an iodine compound that is essential for human health. [38] [39] T 3 binds to thyroid receptor proteins in the cell nucleus and causes metabolic effects through the control of DNA transcription and protein synthesis. [24]
The thyroid system of the thyroid hormones T 3 and T 4 [1] Thyroid hormones are any hormones produced and released by the thyroid gland, namely triiodothyronine (T 3) and thyroxine (T 4). They are tyrosine-based hormones that are primarily responsible for regulation of metabolism. T 3 and T 4 are partially composed of iodine, derived from food. [2]
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