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[18] 30.4–88.9% of those with antisynthetase syndrome report persistent muscular tenderness and myalgia. [19] [20] In antisynthetase syndrome, arthritis is commonly described as a symmetrical, non-erosive polyarthritis of the small hands and feet that can sometimes mimic CTD-associated, rheumatoid, and seronegative inflammatory arthritis. [21]
Anti-Jo1 has been associated with inflammatory myopathies such as polymyositis, dermatomyositis and antisynthetase syndrome. [ 3 ] [ 4 ] It has histidine-tRNA ligase as a target.
PM/Scl overlap syndrome Scleromyositis , is an autoimmune disease (a disease in which the immune system attacks the body). People with scleromyositis have symptoms of both systemic scleroderma and either polymyositis or dermatomyositis , and is therefore considered an overlap syndrome .
[10] [11] [12] Other underlying disorders include vasculitides such as polyarteritis nodosa. [8] Other causes of edema include heart failure, hypoalbuminemia, nephrotic syndrome and venous stasis. The key distinguishing feature is that these conditions don't tend to manifest with pitting edema at the back of the hands.
A tearful executive at the U.S. Internal Revenue Service told staffers on Thursday that about 6,000 employees would be fired.
Elon Musk endorsed AfD, an anti-immigration party that just won the most support of any far-right party since World War II.
The symptoms of DRESS syndrome usually begin 2 to 6 weeks but uncommonly up to 8–16 weeks after exposure to an offending drug. Symptoms generally include fever, an often itchy rash which may be morbilliform or consist mainly of macules or plaques, facial edema (i.e. swelling, which is a hallmark of the disease), enlarged and sometimes painful lymph nodes, and other symptoms due to ...
Image credits: tsupdating During her record-shattering Eras Tour, she reportedly gave $197 million in bonuses to her entire crew. “A lump sum like this gives you the ability to put a down ...