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The term seizure threshold is used to describe the balance between excitatory (glutaminergic) and inhibitory (GABA-ergic) forces in the brain which affect how susceptible a person is to seizures. Those diagnosed with epilepsy or certain other neurological conditions are more vulnerable to seizures if the threshold is reduced, and should be ...
Antipsychotics are not recommended for benzodiazepine withdrawal (or other CNS depressant withdrawal states) especially clozapine, olanzapine or low potency phenothiazines, e.g., chlorpromazine as they lower the seizure threshold and can worsen withdrawal effects; if used extreme caution is required. [148]
Methadone has been shown to reduce neuropathic pain in rat models, primarily through NMDA receptor antagonism. [ citation needed ] NMDA antagonists such as dextromethorphan , ketamine , tiletamine and ibogaine are being studied for their role in decreasing the development of tolerance to opioids and as possible for eliminating addiction ...
Chlorpromazine may be used as an antiemetic in dogs and cats, or, less often, as a sedative before anesthesia. [73] In horses, it often causes ataxia and lethargy and is therefore seldom used. [72] [73] It is commonly used to decrease nausea in animals that are too young for other common antiemetics.
In opioid-induced hyperalgesia, sensitization of pronociceptive mechanisms occurs, resulting in a decrease in the pain threshold, or allodynia. [10] In addition, what appears to be opioid tolerance can be caused by opioid-induced hyperalgesia lowering the baseline pain level, thus masking the drug's analgesic effects. [11]
Similar to fentanyl, a highly potent synthetic opioid, methadone stimulates opioid receptors, making it possible to overdose on the medication, said Matthew Rogalski, an addiction medicine ...
Opioid agonist therapy (OAT) is a treatment in which prescribed opioid agonists are given to patients who live with Opioid use disorder (OUD). [1] In the case of methadone maintenance treatment (MMT), methadone is used to treat dependence on heroin or other opioids, and is administered on an ongoing basis.
1. Ketogenic Diet. Cancer cells rely on glucose for energy to grow. The ketogenic diet is a way to provide an alternative energy source to normal cells in the dog's body while starving the cancer ...