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For children with MRSA-infected bone or joints, treatment is individualized and long-term. Neonates can develop neonatal pustulosis as a result of topical infection with MRSA. [4] Clindamycin is not approved for the treatment of MRSA infection, but it is still used in children for soft-tissue infections. [4]
Staphylococcus aureus is a gram-positive, spherical bacterium that can cause a range of infections in humans and animals. And Methicillin-resistant Staphylococcus aureus (MRSA) is a bacterium that is resistant to many antibiotics. The abbreviation "ST" in MRSA ST398 refers to the sequence type of the bacterium.
Resistance genes interfere with the normal antibiotic function and allow bacteria to grow in the presence of the antibiotic. [4] Resistance in VRSA is conferred by the plasmid-mediated vanA gene and operon. [5] Although VRSA infections are uncommon, VRSA is often resistant to other types of antibiotics and a potential threat to public health ...
One of the most commonly known examples of both antimicrobial resistance and the relationship to the classification of a drug of last resort is the emergence of Staphylococcus aureus (MRSA) (sometimes also referred to as multiple-drug resistant S. aureus due to resistance to non-penicillin antibiotics that some strains of S. aureus have shown ...
Antibiotic resistance, a significant AMR subset, enables bacteria to survive antibiotic treatment, complicating infection management and treatment options. [3] Resistance arises through spontaneous mutation, horizontal gene transfer , and increased selective pressure from antibiotic overuse, both in medicine and agriculture, which accelerates ...
Hence the residual organisms were not antibiotic resistant mutants but rather a subpopulation of what he called ‘persisters’. [7] The formation of bacterial persisters is now known to be a common phenomenon that can occur by the formation of persister cells prior to the antibiotic treatment [8] or in response to a variety of antibiotics. [9]
The use of bacteriophages (viruses which kill bacteria) is a developing area of possible therapeutic treatments. [20] It is necessary to develop new antibiotics over time since the selection of resistant bacteria cannot be prevented completely. This means with every application of a specific antibiotic, the survival of a few bacteria which ...
Narrow-spectrum antibiotics have low propensity to induce bacterial resistance and are less likely to disrupt the microbiome (normal microflora). [3] On the other hand, indiscriminate use of broad-spectrum antibiotics may not only induce the development of bacterial resistance and promote the emergency of multidrug-resistant organisms, but also cause off-target effects due to dysbiosis.