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The terms “basal lamina” and “basement membrane” were often used interchangeably, until it was realised that all three layers seen with the electron microscope constituted the single layer seen with the light microscope. This has led to considerable terminological confusion; if used, the term “basal lamina” should be confined to its ...
The most notable examples of basement membranes is the glomerular basement membrane of the kidney, by the fusion of the basal lamina from the endothelium of glomerular capillaries and the podocyte basal lamina, [9] and between lung alveoli and pulmonary capillaries, by the fusion of the basal lamina of the lung alveoli and of the basal lamina ...
Basal cells are bound to each other by desmosomes, and to the basal lamina of the basement membrane by hemidesmosomes. These junctions help to create one tightly bound, continuous tissue layer that can endure mechanical stress and effectively function as a connection between the basement membrane and remaining epithelial tissue. [4]
They are major constituents of the basement membrane, namely the basal lamina (the protein network foundation for most cells and organs). Laminins are vital to biological activity, influencing cell differentiation, migration, and adhesion. [1] [2]
The glomerular basement membrane of the kidney is the basal lamina layer of the glomerulus.The glomerular endothelial cells, the glomerular basement membrane, and the filtration slits between the podocytes perform the filtration function of the glomerulus, separating the blood in the capillaries from the filtrate that forms in Bowman's capsule. [1]
The basement membrane acts as a selectively permeable membrane that determines which substances will be able to enter the epithelium. [2]: 3 The basal lamina is made up of laminin (glycoproteins) secreted by epithelial cells. The reticular lamina beneath the basal lamina is made up of collagen proteins secreted by connective tissue.
The basal lamina of the filtration barrier is composed of three layers. The first layer is the lamina rara externa, adjacent to the podocyte processes. The second layer is the lamina rara interna, adjacent to the endothelial cells. The final layer is the lamina densa which is a darker central zone of the basal lamina.
In biology, the extracellular matrix (ECM), [1] [2] also called intercellular matrix (ICM), is a network consisting of extracellular macromolecules and minerals, such as collagen, enzymes, glycoproteins and hydroxyapatite that provide structural and biochemical support to surrounding cells.