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Despite the name, nausea or vomiting can occur at any time during the day. [2] Typically the symptoms occur between the 4th and 16th weeks of pregnancy. [2] About 10% of women still have symptoms after the 20th week of pregnancy. [2] A severe form of the condition is known as hyperemesis gravidarum and results in weight loss. [1] [6]
Vomiting is a common condition affecting about 50% of pregnant women, with another 25% having nausea. [53] However, the incidence of HG is only 0.3–1.5%. [4] After preterm labor, hyperemesis gravidarum is the second most common reason for hospital admission during the first half of pregnancy. [16]
Pyridoxine/doxylamine, sold under the brand name Diclectin among others, is a combination of pyridoxine hydrochloride (vitamin B 6) and doxylamine succinate.It is generally used for nausea and vomiting of pregnancy (morning sickness); even though its efficacy has not been proven and subsequent research has led to the removal of recommendations in medical journals.
Some 70% of women experience nausea and vomiting during pregnancy, including in its most severe form, known as hyperemesis gravidarum (HG), according to the study.
Most often, nausea and vomiting symptoms during pregnancy resolve in the first trimester, however, some continue to experience symptoms. Hyperemesis gravidarum is diagnosed by the following criteria: greater than 3 vomiting episodes per day, ketonuria, and weight loss of more than 3 kg or 5% of body weight.
Doxylamine is used in the combination drug pyridoxine/doxylamine to treat morning sickness (nausea and vomiting of pregnancy). [ 19 ] [ 20 ] [ 21 ] It is the only medication approved by the United States Food and Drug Administration for the treatment of morning sickness.
Vomiting (also known as emesis, puking and throwing up) [a] is the involuntary, forceful expulsion of the contents of one's stomach through the mouth and sometimes the nose. [ 1 ]
In cases of gastroenteritis, serotonin antagonists such as ondansetron were found to suppress nausea and vomiting, as well as reduce the need for IV fluid resuscitation. [22] The combination of pyridoxine and doxylamine is the first line treatment for pregnancy-related nausea and vomiting. [22]
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