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  2. Clearance (pharmacology) - Wikipedia

    en.wikipedia.org/wiki/Clearance_(pharmacology)

    There is an important relationship between clearance, elimination half-life and distribution volume. The elimination rate constant of a drug K e l {\displaystyle K_{el}} is equivalent to total clearance divided by the distribution volume

  3. Trazodone - Wikipedia

    en.wikipedia.org/wiki/Trazodone

    Trazodone, sold under many brand names, [1] is an antidepressant medication [20] used to treat major depressive disorder, anxiety disorders, and insomnia. [20] It is a phenylpiperazine compound of the serotonin antagonist and reuptake inhibitor (SARI) class.

  4. Equianalgesic - Wikipedia

    en.wikipedia.org/wiki/Equianalgesic

    An equianalgesic chart can be a useful tool, but the user must take care to correct for all relevant variables such as route of administration, cross tolerance, half-life and the bioavailability of a drug. [5] For example, the narcotic levorphanol is 4–8 times stronger than morphine, but also has a much longer half-life. Simply switching the ...

  5. Biological half-life - Wikipedia

    en.wikipedia.org/wiki/Biological_half-life

    In clinical practice, this means that it takes 4 to 5 times the half-life for a drug's serum concentration to reach steady state after regular dosing is started, stopped, or the dose changed. So, for example, digoxin has a half-life (or t ⁠ 1 / 2 ⁠ ) of 24–36 h; this means that a change in the dose will take the best part of a week to ...

  6. Median lethal dose - Wikipedia

    en.wikipedia.org/wiki/Median_lethal_dose

    In toxicology, the median lethal dose, LD 50 (abbreviation for "lethal dose, 50%"), LC 50 (lethal concentration, 50%) or LCt 50 is a toxic unit that measures the lethal dose of a given substance. [1] The value of LD 50 for a substance is the dose required to kill half the members of a tested population after a specified test duration.

  7. EC50 - Wikipedia

    en.wikipedia.org/wiki/EC50

    The EC 50 of a quantal dose response curve represents the concentration of a compound where 50% of the population exhibit a response, [5] after a specified exposure duration. For clarification, a graded dose response curve shows the graded effect of the drug (y axis) over the dose of the drug (x axis) in one or an average of subjects.

  8. Dogs don't actually age 7 times faster than humans, new study ...

    www.aol.com/lifestyle/dogs-dont-actually-age-7...

    Say you have a 4-year-old Labrador named Comet — with the new equation, Comet's real "dog age" would be slightly older than 53. The reason for the difference is actually pretty simple.

  9. List of veterinary drugs - Wikipedia

    en.wikipedia.org/wiki/List_of_veterinary_drugs

    amitriptyline – tricyclic antidepressant used to treat separation anxiety, excessive grooming dogs and cats; amlodipine – calcium channel blocker used to decrease blood pressure; amoxicillin – antibacterial; apomorphine – emetic (used to induce vomiting) artificial tears – lubricant eye drops used as a tear supplement

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