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The hemagglutination assay or haemagglutination assay (HA) and the hemagglutination inhibition assay (HI or HAI) were developed in 1941–42 by American virologist George Hirst as methods for quantifying the relative concentration of viruses, bacteria, or antibodies.
Hemagglutination, or haemagglutination, is a specific form of agglutination that involves red blood cells (RBCs). It has two common uses in the laboratory: blood typing and the quantification of virus dilutions in a haemagglutination assay .
Consequently, those viruses bound to antibodies are unable to link RBCs, meaning that a test’s positive result due to hemagglutination has been inhibited. On the contrary, if hemagglutination occurs, the test will result negative. A schematic diagram of the experimental setup to detect hemagglutination for blood typing.
Hemagglutinin (HA) in influenza A virus (IAV) has at least 18 different subtypes. [7] These subtypes are named H1 through H18. H16 was discovered in 2004 on IAVs isolated from black-headed gulls from Sweden and Norway.
This Widal test was the first example of serum diagnosis. Austrian physician Karl Landsteiner found another important practical application of the agglutination reaction in 1900. Landsteiner's agglutination tests and his discovery of ABO blood groups was the start of the science of blood transfusion and serology which has made transfusion ...
This domain is suggested to be a carbohydrate-dependent haemagglutination activity site. [ 1 ] In Bordetella pertussis , the infectious agent in childhood whooping cough , filamentous haemagglutinin (FHA) is a surface-exposed and secreted protein that acts as a major virulence attachment factor, functioning as both a primary adhesin and an ...
(The Center Square) – Efforts to push back retirement of the F-15E Strike Eagles and save more than 500 jobs at a U.S. Air Force base in North Carolina could be ready for the president's ...
Blood compatibility testing is routinely performed before a blood transfusion.The full compatibility testing process involves ABO and RhD (Rh factor) typing; screening for antibodies against other blood group systems; and crossmatching, which involves testing the recipient's blood plasma against the donor's red blood cells as a final check for incompatibility.