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N-acetylphosphatidylethanolamine-hydrolysing phospholipase D (EC 3.1.4.54, NAPE-PLD, anandamide-generating phospholipase D, N-acyl phosphatidylethanolamine phospholipase D, NAPE-hydrolyzing phospholipase D) is an enzyme with systematic name N-acetylphosphatidylethanolamine phosphatidohydrolase. [1] [2] It catalyses the following chemical reaction
N-acyl phosphatidylethanolamine phospholipase D (NAPE-PLD) is an enzyme that catalyzes the release of N-acylethanolamine (NAE) from N-acyl-phosphatidylethanolamine (NAPE). This is a major part of the process that converts ordinary lipids into chemical signals like anandamide and oleoylethanolamine .
A hydrophobic cavity in NAPE-PLD provides an entryway for the substrate NAPE into the active site, where a binuclear zinc center orchestrates its hydrolysis. Unexpectedly, the structure unveils bile acids bind the membrane enzyme, enhancing dimer assembly and enabling catalysis.
NAPE-PLD may refer to: N-acyl-phosphatidylethanolamine-hydrolysing phospholipase D [ wikidata ] N-acyl phosphatidylethanolamine-specific phospholipase D , an enzyme
In traditional Japanese culture, the nape (項, unaji) was one of the few areas of the body (other than face and hands) left uncovered by women's attire. The nape of a woman's neck held a strong attraction for many Japanese men (see oshiroi). [2] In Egyptian and Lebanese culture, slapping the nape is considered a gesture of utter humiliation. [3]
The German National Action Plan on Energy Efficiency (NAPE) (German: Nationaler Aktionsplan Energieeffizienz) is the National Energy Efficiency Action Plan (NEEAP) for Germany. [1] The plan was commissioned under EU Energy Efficiency Directive 2012/27/EU of the European Union and released on 3 December 2014. [ 2 ]
The *ist DS was a lower-prices follow-on to the Pentax *ist D. In September 2005 the Digital Imaging Websites Association (DIWA), a worldwide organization of collaborating websites, announced that Pentax had received their first DIWA Award for a DSLR camera. The *ist DS model was awarded with a Silver medal for outstanding test results.
White Plume Mountain is set in the World of Greyhawk, a campaign setting for Dungeons & Dragons. [5] The module is a dungeon crawl, [1] precipitated by the theft of three magical, sentient weapons: [6] a trident named Wave, a war hammer named Whelm, and a sword named Blackrazor (all three were introduced in this adventure). [1]