Search results
Results from the WOW.Com Content Network
22173 Ensembl ENSG00000077498 ENSMUSG00000004651 UniProt P14679 P11344 RefSeq (mRNA) NM_000372 NM_011661 NM_001317397 RefSeq (protein) NP_000363 NP_001304326 NP_035791 Location (UCSC) Chr 11: 89.18 – 89.3 Mb Chr 7: 87.07 – 87.14 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Tyrosinase is an oxidase that is the rate-limiting enzyme for controlling the production of melanin. The ...
This page was last edited on 19 September 2024, at 19:31 (UTC).; Text is available under the Creative Commons Attribution-ShareAlike 4.0 License; additional terms may apply.
22178 Ensembl ENSG00000107165 ENSMUSG00000005994 UniProt P17643 P07147 RefSeq (mRNA) NM_000550 NM_001282014 NM_001282015 NM_031202 RefSeq (protein) NP_000541 NP_001268943 NP_001268944 NP_112479 Location (UCSC) Chr 9: 12.69 – 12.71 Mb Chr 4: 80.75 – 80.77 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Tyrosinase-related protein 1, also known as TYRP1, is an intermembrane enzyme ...
L-Tyrosine or tyrosine (symbol Tyr or Y) [2] or 4-hydroxyphenylalanine is one of the 20 standard amino acids that are used by cells to synthesize proteins.It is a conditionally essential amino acid with a polar side group.
Other names in common use include beta-tyrosinase, and L-tyrosine phenol-lyase (deaminating). This enzyme participates in tyrosine metabolism and nitrogen metabolism . It employs one cofactor , pyridoxal phosphate .
The tyrosinase (TYR) gene is located on chromosome 11q14. This protein coding gene produces tyrosinase, an enzyme which catalyzes a total of three steps in the conversion of tyrosine to the end product, melanin. [7] This enzyme and conversion process takes place within melanocytes, which are specialized cells for melanin production. [8]
Several skin whitening agents, including tyrosinase inhibitors, have been found to cause an increase in the expression of tyrosinase, which by itself would increase melanin synthesis. [ 41 ] Microphthalmia-associated transcription factor (MITF) is the master transcription factor that controls the expression of TYR, TRP1, and TRP2, MART1 ...
While the active site of both tyrosinase and catechol oxidase contain the di-copper center, variations in each enzyme’s respective structure result in differing activity. In catechol oxidase, a phenylalanine side-chain (Phe261) is above one of the copper centers and prevents the substrate from coordinating with both copper ions in the active ...