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First, they effectively reduce blood pressure. Loop and thiazide diuretics are secreted from the proximal tubule via the organic anion transporter-1 and exert their diuretic action by binding to the Na(+)-K(+)-2Cl(-) co-transporter type 2 in the thick ascending limb and the Na(+)-Cl(-) co-transporter in the distal convoluted tubule, respectively.
Intravenous therapy (abbreviated as IV therapy) is a medical technique that administers fluids, medications and nutrients directly into a person's vein.The intravenous route of administration is commonly used for rehydration or to provide nutrients for those who cannot, or will not—due to reduced mental states or otherwise—consume food or water by mouth.
Flushing with saline should be painless if the cannula is in its proper place, although if the saline is not warmed there may be a cold sensation running up the vein. A painful flush may indicate tissuing or phlebitis and is an indication that the cannula should be relocated. [1] Solutions other than normal saline may be used.
Common side effects include dry mouth, dizziness, headaches, hypotension, and sleepiness. [13] Severe side effects may include hallucinations, heart arrhythmias, and confusion. [14] If rapidly stopped, withdrawal effects may occur, such as a dangerous rise in blood pressure. [13] Use during pregnancy or breastfeeding is not recommended. [14]
Hydrochlorothiazide, sold under the brand name Hydrodiuril among others, is a diuretic medication used to treat hypertension and swelling due to fluid build-up. [4] Other uses include treating diabetes insipidus and renal tubular acidosis and to decrease the risk of kidney stones in those with a high calcium level in the urine. [4]
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Side effects may include allergic reactions, high blood potassium, hypervolemia, and high blood calcium. [2] It may not be suitable for mixing with certain medications and some recommend against use in the same infusion as a blood transfusion. [4] Ringer's lactate solution has a lower rate of acidosis as compared with normal saline.