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Low-dose and high-dose variations of the test exist. [4] The test is given at low (usually 1–2 mg) and high (8 mg) doses of dexamethasone, and the levels of cortisol are measured to obtain the results. [5] A low dose of dexamethasone suppresses cortisol in individuals with no pathology in endogenous cortisol production.
Both of these short tests last for about an hour and provide the same information. Studies have shown the cortisol response of the adrenals is the same for the low-dose and conventional-dose tests. [9] [10] The prolonged-stimulation test, which is also called a long conventional-dose test, can last up to 48 hours. This form of the test can ...
Test results should, therefore, always be interpreted using the reference range from the laboratory that produced the result. [ 57 ] [ 58 ] [ 59 ] An individual's cortisol levels can be detected in blood, serum, urine, saliva, and sweat.
The Trier social stress test (TSST) is a laboratory procedure used to reliably induce ... the cortisol responses of females depends on which phase of their menstrual ...
Evocative/suppression testing refers to a class of tests performed where one substance is measured both before and after the administration of another substance to determine if the levels are stimulated ("evocative") or suppressed.
To confirm inappropriately low cortisol secretion, testing can include baseline morning cortisol level in the blood or morning cortisol level in the saliva. [2] Cortisol levels typically peak in the morning; thus, low values indicate true adrenal insufficiency. [2] Urinary free cortisol can also be measured, but are not necessary for diagnosis. [2]
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