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Tetrahydrobiopterin deficiency (THBD, BH 4 D) is a rare metabolic disorder that increases the blood levels of phenylalanine.Phenylalanine is an amino acid obtained normally through the diet, but can be harmful if excess levels build up, causing intellectual disability and other serious health problems.
Phe—phenylalanine, Tyr—tyrosine, pHPP—p-hydroxyphenylpyruvate, hga—homogentisate, maa—maleylacetoacetate, faa—fumarylacetoacetate. Enzymes: PAH—phenylalanine hydroxylase, TAT—tyrosine transaminase, HPD—4-hydroxyphenylpyruvate dioxygenase, HGD—homogentisate oxidase, MAAI—maleylacetoacetate isomerase, FAH—fumarylacetoacetase.
Worms and other internal parasites can be treated easily but are some of the most common problems seen in dogs. Some of the internal parasites that cause diarrhea and loose stools in puppies ...
Tyrosine is semi-essential; therefore, it can be synthesized by the animal, but only from phenylalanine. Phenylketonuria, a genetic disorder that occurs as a result of the inability to breakdown phenylalanine, is due to a lack of the enzyme phenylalanine hydroxylase. A dietary lack of tryptophan can cause stunted skeletal development. [9]
Hawkinsinuria is an autosomal dominant metabolic disorder affecting the metabolism of tyrosine. [1] [2] Normally, the breakdown of the amino acid tyrosine involves the conversion of 4-hydroxyphenylpyruvate to homogentisate by 4-hydroxyphenylpyruvate dioxygenase. Complete deficiency of this enzyme would lead to tyrosinemia III. In rare cases ...
It is a rare disease in dogs, with cats seven to ten times more likely to be infected. The disease in dogs can affect the lungs and skin, but more commonly the eye and central nervous system. [20] Ringworm is a fungal skin disease that in dogs is caused by Microsporum canis (70%), Microsporum gypseum (20%), and Trichophyton mentagrophytes (10% ...
To understand how the absence of this enzyme affects the body, we must look at the BH 4 synthesis pathway. PTPS is an intermediate in this cycle and is needed to convert 7,8 - dihydroneopterin triphosphate to 6-Pyruvoyltetrahydryobiopterin. 6-Pyruvoyltetrahydryobiopterin is converted into BH 4 (Tetrahydrobiopterin), but since it stops at 6-Pyruvoyltetrahydrobiopterin no BH 4 is made. [6]
Image credits: dogswithjobs There’s a popular saying that cats rule the Internet, and research has even found that the 2 million cat videos on YouTube have been watched more than 25 billion ...
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