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Most Pax genes contain a homeobox and a paired domain that also binds DNA to increase binding specificity, though some Pax genes have lost all or part of the homeobox sequence. [46] Pax genes function in embryo segmentation , nervous system development, generation of the frontal eye fields , skeletal development, and formation of face structures.
Homeobox protein Hox-A7 is a protein that in humans is encoded by the HOXA7 gene. [5] [6] [7] In vertebrates, the genes encoding the class of transcription factors called homeobox genes are found in clusters named A, B, C, and D on four separate chromosomes. Expression of these proteins is spatially and temporally regulated during embryonic ...
HNF1 homeobox A (hepatocyte nuclear factor 1 homeobox A), also known as HNF1A, is a human gene on chromosome 12. [ 5 ] [ 6 ] [ 7 ] It is ubiquitously expressed in many tissues and cell types. [ 8 ] The protein encoded by this gene is a transcription factor that is highly expressed in the liver and is involved in the regulation of the expression ...
This gene is a member of the Antp homeobox family and encodes a protein with a homeobox DNA-binding domain. It is included in a cluster of homeobox B genes located on chromosome 17 . The encoded nuclear protein functions as a sequence-specific transcription factor that is involved in cell proliferation and differentiation .
Homeobox protein Meis2 is a protein that in humans is encoded by the MEIS2 gene. [ 5 ] [ 6 ] This gene encodes a homeobox protein belonging to the TALE ('three amino acid loop extension') family of homeodomain-containing proteins.
The Lim gene family is a subfamily of homeobox genes. [7] The homeobox genes are essential in organizing the body plan of an organism and all contain the same conserved homeodomain of amino acids. [8] Evidence that Lim-1 is essential to a developing organism is its conservation throughout evolution and presence in a variety of organisms. [7]
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HOXB6 gene is only expressed in erythroid progenitor cells, which are the precursor to red blood cells used for transport of oxygen and carbon dioxide throughout the body. During development, the formation of the HOX gene factor happens in the first stages of fetal development , namely soon after the establishment of the mesoderm , which is the ...