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After oral or intravenous administration, isavuconazonium is rapidly hydrolysed by esterases in blood or the gastrointestinal tract to the active form, isavuconazole. [7] [8] [15] Isavuconazole works by inhibition of lanosterol 14α-demethylase, the enzyme responsible for converting lanosterol to ergosterol by demethylation.
Posaconazole, sold under the brand name Noxafil among others, is a triazole antifungal medication. [ 7 ] [ 8 ] It was approved for medical use in the European Union in October 2005, [ 6 ] and in the United States in September 2006.
Current antifungal agents the fungi are not resistant to are posaconazole, voriconazole, and azole isavuconazole. [ 13 ] In 2006, a free-living eastern box turtle , Terrapene carolina carolina , was found with a form of phaeohyphomycosis and was brought in the Wildlife Center of Virginia .
The United States Food and Drugs Administration is warning pet owners about a common medication given to pets to treat arthritis. The F.D.A. now says that the drug Librela may be associated with ...
Dogs are ten times more likely to be infected than humans. The disease in dogs can affect the eyes, brain, lungs, skin, or bones. [15] Histoplasmosis* is a fungal disease caused by Histoplasma capsulatum that affects both dogs and humans. The disease in dogs usually affects the lungs and small intestine. [16]
Dogs and cats often ingest foreign objects, which can cause blockages in their gastrointestinal tract. Surgery to remove these items typically costs between $800 and $5,000, depending on the ...
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