Search results
Results from the WOW.Com Content Network
Positive feedback loops play a role by switching cells from low to high Cdk-activity. The interaction between the two types of loops is evident in mitosis. While positive feedback initiates mitosis, a negative feedback loop promotes the inactivation of the cyclin-dependent kinases by the anaphase-promoting complex.
This is due to a complex feedback mechanism which exists between the androgen receptor and the PI3K pathway. [18] As in other tumour types, mutations in key genes of this pathway can lead to hyperactivation of this pathway, for example in PIK3CA, [ 19 ] [ 20 ] Increases in the copy number of PIK3CA and increased mRNA expression also increases ...
Positive feedback occurs when a gene activates itself directly or indirectly via a double negative feedback loop. Genetic engineers have constructed and tested simple positive feedback networks in bacteria to demonstrate the concept of bistability. [28] A classic example of positive feedback is the lac operon in E. coli. Positive feedback plays ...
Epithelial polarity is one example of the cell polarity that is a fundamental feature of many types of cells. Epithelial cells feature distinct 'apical', 'lateral' and 'basal' plasma membrane domains. Epithelial cells connect to one another via their lateral membranes to form epithelial sheets that line cavities and surfaces throughout the ...
Within molecular and cell biology, temporal feedback, also referred to as interlinked or interlocked feedback, is a biological regulatory motif in which fast and slow positive feedback loops are interlinked to create "all or none" switches. This interlinking produces separate, adjustable activation and de-activation times.
For example, in metazoan cells, the PAR-3/PAR-6/aPKC complex plays a fundamental role in cell polarity. While the biochemical details may vary, some of the core principles such as negative and/or positive feedback between different molecules are common and essential to many known polarity systems.
They said the sector looks more attractive than discretionary stocks, even though those stocks led November's gains with a 13.3% rise. The analysts downgraded discretionary stocks, excluding ...
In membrane biology, the Hodgkin cycle is a key component of membrane physiology that describes bioelectrical impulses, especially prevalent in neural and muscle tissues. It was identified by British physiologist and biophysicist Sir Alan Lloyd Hodgkin.