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The cure rate, even for metastatic gestational choriocarcinoma, is more than 90% when using chemotherapy for invasive mole and choriocarcinoma. [7] As of 2019, treatment with either single-agent methotrexate or actinomycin-D is recommended for low-risk disease, while intense combination regimens including EMACO (etoposide, methotrexate ...
Gestational choriocarcinoma is a form of gestational trophoblastic neoplasia, which is a type of gestational trophoblastic disease (GTD), that can occur during pregnancy. It is a rare disease where the trophoblast , a layer of cells surrounding the blastocyst , undergoes abnormal developments, leading to trophoblastic tumors .
Sometimes it may develop into an invasive mole, or, more rarely into a choriocarcinoma. A choriocarcinoma is likely to spread quickly, [2] [3] but is very sensitive to chemotherapy, and has a very good prognosis. Trophoblasts are of particular interest to cell biologists because, like cancer, they can invade tissue (the uterus), but unlike ...
Management of GTN requires pathology review, treatment options and monitoring of hCG. Therefore, it can be treated with curettage, hysterectomy and single agent or multi agent chemotherapy. [ 4 ] Although this group of diseases are highly susceptible to chemotherapy, prognosis depends on the type of GTN and whether the tumor has spread to other ...
Theca lutein cyst is a type of bilateral functional ovarian cyst filled with clear, straw-colored fluid. These cysts result from exaggerated physiological stimulation (hyperreactio luteinalis) due to elevated levels of beta-human chorionic gonadotropin (beta-hCG) or hypersensitivity to beta-hCG.
A micrograph showing a choriocarcinoma spread to the lung [13] Choriocarcinomas are exceptionally rare which account for 2.1%-3.4% of all OGCTs. [ 14 ] Under gross examination, the syncytiotrophoblast cells are aligned in a plexiform arrangement with the mononucleated cytotrophoblast cells surrounding the foci of the hemorrhage. [ 1 ]
Rural delivery always has been a challenge for the Postal Service, which has developed guidelines over the years for how to balance its customers’ needs with the need to operate safely and ...
Immunohistochemistry often shows positive staining for hPL, [4] [5] keratin, [5] Mel-CAM, [5] and EGFR., [4] This immunohistochemical profile, particularly the strong positivity for hPL and Mel-CAM, along with the negative or focal staining for β-hCG and p63, helps distinguish PSTT from other types of gestational trophoblastic neoplasia such as choriocarcinoma and epithelioid trophoblastic ...