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Dimethyl fumarate (DMF) is the methyl ester of fumaric acid and is named after the earth smoke plant (Fumaria officinalis). [8] Dimethyl fumarate combined with three other fumaric acid esters (FAEs) is solely licensed in Germany as an oral therapy for psoriasis (brand name Fumaderm). [9]
Fumaric acid or trans-butenedioic acid is an organic compound with the formula HO 2 CCH=CHCO 2 H. A white solid, fumaric acid occurs widely in nature. It has a fruit-like taste and has been used as a food additive. Its E number is E297. [3] The salts and esters are known as fumarates. Fumarate can also refer to the C 4 H 2 O 2− 4 ion (in ...
Another set of treatments for moderate to severe psoriasis are fumaric acid esters (FAE), which may be similar in effectiveness to methotrexate. [108] Apremilast (Otezla, Celgene) is an oral small-molecule inhibitor of the enzyme phosphodiesterase 4, which plays an important role in chronic inflammation associated with psoriasis. [109]
A CDC study on listeria outbreaks from 1998 through 2014 attributed 30% of the cases to soft cheese, which due to its higher moisture content, is a better host for the pathogen than hard cheese ...
XenoPort Reports Favorable Metabolism and Pharmacokinetics of XP23829, a Novel Fumaric Acid Ester, in Phase 1 Trial Intends to Advance Development for Potential RRMS and/or Psoriasis Treatment ...
An ester of carboxylic acid. R stands for any group (organic or inorganic) and R′ stands for organyl group. In chemistry, an ester is a compound derived from an acid (organic or inorganic) in which the hydrogen atom (H) of at least one acidic hydroxyl group (−OH) of that acid is replaced by an organyl group (−R).
Hypochlorous acid (HOCl) is a naturally occurring compound produced by our white blood cells to fight infection and inflammation, says Mona Gohara, M.D., board-certified dermatologist at ...
In time, Zoe may suffer some of the same problems as Taoufike, a 13-year-old boy who lives in one of Parkash’s buildings. In 2005, a blood test revealed that his blood level was 32 micrograms per deciliter — an exceptionally high rate that’s over six times the amount requiring close medical monitoring under CDC guidelines.