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Lymphocyte-activation gene 3, also known as LAG-3, is a protein which in humans is encoded by the LAG3 gene. [5] LAG3, which was discovered in 1990 [6] and was designated CD223 (cluster of differentiation 223) after the Seventh Human Leucocyte Differentiation Antigen Workshop in 2000, [7] is a cell surface molecule with diverse biological effects on T cell function but overall has an immune ...
Relatlimab is a Lymphocyte activation gene-3 (LAG-3) inhibitor. [ 2 ] [ 5 ] It is under development by Bristol-Myers Squibb . [ 2 ] [ 5 ] It is made using Chinese hamster ovary cells .
It contains nivolumab, a programmed death receptor-1 (PD-1) blocking antibody, and relatlimab, a lymphocyte activation gene-3 (LAG-3) blocking antibody. [10] It is given by intravenous infusion. [10] The combination was approved for medical use in the United States in March 2022, [10] [12] and in the European Union in September 2022. [11]
LAG-3 Inhibitors. In 2022, the FDA approved a combination of relatlimab and nivolumab to be marketed under the name Opdualag for people aged 12 or older with previously untreated melanoma that cannot be removed surgically or has spread (metastasized) within the body. Relatlimab blocks a protein on immune cells called LAG-3. [22]
Eftilagimod alpha (lab names: IMP321 or LAG-3Ig) is a soluble dimeric recombinant form of LAG-3, being a fusion protein with immunoglobulin, designed to activate antigen presenting cells. Immutep established in 2008 that the product could induce activation of dendritic cell and monocytes, resulting in T cell expansion. [ 10 ]
On Wednesday, Merck & Co Inc (NYSE:MRK) released topline data from the KEYFORM-007 Phase 3 study of the fixed-dose combination of favezelimab and pembrolizumab versus the standard of care for ...
In molecular biology, the transcriptional activator LAG-3 is a transcriptional activator protein. The C. elegans Notch pathway, involved in the control of growth, differentiation and patterning in animal development, relies on either of the receptors GLP-1 or LIN-12. [1]
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